{"id":4728,"date":"2026-05-08T09:54:10","date_gmt":"2026-05-08T07:54:10","guid":{"rendered":"https:\/\/imast.biz\/?post_type=pubblicazione&#038;p=4728"},"modified":"2026-05-08T09:54:10","modified_gmt":"2026-05-08T07:54:10","slug":"micellar-drug-nanocarriers-and-biomembranes-how-do-they-interact","status":"publish","type":"pubblicazione","link":"https:\/\/imast.biz\/en\/pubblicazione\/micellar-drug-nanocarriers-and-biomembranes-how-do-they-interact\/","title":{"rendered":"Micellar drug nanocarriers and biomembranes: how do they interact?"},"content":{"rendered":"<div class=\"body\">\n<div class=\"row-fluid main-body\">\n<div class=\"span12\">\n<div class=\"item-page\">\n<div>\n<p>Pluronic based formulations are among the most successful nanomedicines and block-copolymer micelles including drugs that are undergoing phase I\/II studies as anticancer agents. Using coarse-grained models, molecular dynamics simulations of large-scale systems, modeling Pluronic micelles interacting with DPPC lipid bilayers, on the \u03bcs timescale have been performed. Simulations show, in agreement with experiments, the release of Pluronic chains from the micelle to the bilayer. This release changes the size of the micelle. Moreover, the presence of drug molecules inside the core of the micelle has a strong influence on this process. The picture emerging from the simulations is that the micelle stability is a result of an interplay of drug\u2013micelle core and block-copolymer\u2013bilayer interactions. The equilibrium size of the drug vector shows a strong dependency on the hydrophobicity of the drug molecules embedded in the core of the micelle. In particular, the radius of the micelle shows an abrupt increase in a very narrow range of drug molecule hydrophobicity.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"template":"","meta":{"_acf_changed":false},"class_list":["post-4728","pubblicazione","type-pubblicazione","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Micellar drug nanocarriers and biomembranes: how do they interact? | IMAST<\/title>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Micellar drug nanocarriers and biomembranes: how do they interact? | IMAST\" \/>\n<meta property=\"og:description\" content=\"Pluronic based formulations are among the most successful nanomedicines and block-copolymer micelles including drugs that are undergoing phase I\/II studies as anticancer agents. Using coarse-grained models, molecular dynamics simulations of large-scale systems, modeling Pluronic micelles interacting with DPPC lipid bilayers, on the \u03bcs timescale have been performed. Simulations show, in agreement with experiments, the release [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/imast.biz\/en\/pubblicazione\/micellar-drug-nanocarriers-and-biomembranes-how-do-they-interact\/\" \/>\n<meta property=\"og:site_name\" content=\"IMAST\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/imast.biz\\\/en\\\/pubblicazione\\\/micellar-drug-nanocarriers-and-biomembranes-how-do-they-interact\\\/\",\"url\":\"https:\\\/\\\/imast.biz\\\/en\\\/pubblicazione\\\/micellar-drug-nanocarriers-and-biomembranes-how-do-they-interact\\\/\",\"name\":\"Micellar drug nanocarriers and biomembranes: how do they interact? | IMAST\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/imast.biz\\\/en\\\/#website\"},\"datePublished\":\"2026-05-08T07:54:10+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/imast.biz\\\/en\\\/pubblicazione\\\/micellar-drug-nanocarriers-and-biomembranes-how-do-they-interact\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/imast.biz\\\/en\\\/pubblicazione\\\/micellar-drug-nanocarriers-and-biomembranes-how-do-they-interact\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/imast.biz\\\/en\\\/pubblicazione\\\/micellar-drug-nanocarriers-and-biomembranes-how-do-they-interact\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/imast.biz\\\/en\\\/home\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Micellar drug nanocarriers and biomembranes: how do they interact?\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/imast.biz\\\/en\\\/#website\",\"url\":\"https:\\\/\\\/imast.biz\\\/en\\\/\",\"name\":\"IMAST\",\"description\":\"Distretto tecnologico per l&#039;ingegneria dei materiali polimerici e compositi e strutture\",\"publisher\":{\"@id\":\"https:\\\/\\\/imast.biz\\\/en\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/imast.biz\\\/en\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/imast.biz\\\/en\\\/#organization\",\"name\":\"IMAST\",\"url\":\"https:\\\/\\\/imast.biz\\\/en\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/imast.biz\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/imast.biz\\\/wp-content\\\/uploads\\\/2026\\\/03\\\/logo-imast.png\",\"contentUrl\":\"https:\\\/\\\/imast.biz\\\/wp-content\\\/uploads\\\/2026\\\/03\\\/logo-imast.png\",\"width\":600,\"height\":257,\"caption\":\"IMAST\"},\"image\":{\"@id\":\"https:\\\/\\\/imast.biz\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Micellar drug nanocarriers and biomembranes: how do they interact? | IMAST","robots":{"index":"noindex","follow":"follow"},"og_locale":"en_US","og_type":"article","og_title":"Micellar drug nanocarriers and biomembranes: how do they interact? | IMAST","og_description":"Pluronic based formulations are among the most successful nanomedicines and block-copolymer micelles including drugs that are undergoing phase I\/II studies as anticancer agents. 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